Covid vaccine after effects duration11/22/2023 The following query demonstrates the PubMed search strategy: Supplementary material 1 includes the search strategy for all the databases. The search was conducted on September 15, 2021. We designed our search strategy using the keywords from previous articles and the medical subject headings (MeSH) terms. The aim of the present study was to evaluate the safety and side effects of the inactivated vaccines of COVID-19 and Novavax.Ĭonsistent with the Cochrane handbook of systematic reviews, PubMed, Scopus, Web of Science, and Cochrane were selected databases in this study. A systematic search of relevant records was carried out in the online databases using selected keywords on September 15th, 2021. ![]() This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To give additional data to optimize the use of the COVID-19 vaccines, we performed a systematic review of the adverse events of the existing inactivated vaccines and Novavax to determine their safety. An early study found that the vaccines, NVX-CoV2373 (Novavax, USA) and ZF2001 (Longcom, China), both of which imitate the receptor-binding domain (RBD) of the SARS-COV-2 S protein, successfully prevent infection and generate high antibody titers against the SARS-COV-2 S protein.Įvidence to assist in selection of vaccines for population-based immunization in diverse areas is limited. ![]() NVX-CoV2373 (Novavax, USA) and ZF2001 (Longcom, China), two COVID-19 protein subunit vaccines, are now undergoing phase-3 clinical studies ( 18, 19). SARS-CoV-2 vaccines manufactured by Sinovac Life Sciences/CoronaVac (China) and Beijing Institute of Biological Products/Sinopharm (China) have received conditional marketing approval from the China National Medical Products Administration and have been placed on WHO's Emergency Use Listing ( 16, 17) so far. SARS-CoV-2 vaccines have shown strong neutralizing antibody responses and effectiveness against COVID-19 during clinical studies conducted in different countries ( 11- 15). Inactivated SARS-CoV-2 vaccines have been shown to generate significant levels of neutralizing antibody titers in mice, rats, guinea pigs, rabbits, and nonhuman primates ( 8- 10). Having been used for a long time gives them several benefits, such as well-developed manufacturing methods and the ability to easily scale production and storage up and down. Influenza and poliovirus vaccines have been demonstrated to be safe and efficacious when made from inactivated viruses ( 7). Because there is not yet a standard treatment for COVID-19, vaccines must be administered quickly to stop the global pandemic. ![]() It is still important to curb thevirus by wearing masks and avoiding public gatherings or closing schools, even though these measures have had a big impact on daily life and the world economy ( 6). This has been a huge problem for health systems around the world. Given these characteristics, it quickly spread from its source to other areas and countries, causing a pandemic across the world. ![]() COVID-19 spreads more easily through droplets and aerosols than SARS, MERS, and influenza ( 5). COVID-19 manifestations are coughing, fever or chills, and shortness of breath thus, it may be challenging to distinguish it from influenza ( 3- 5). The virus is similar to the other two coronaviruses, SARS-CoV and MERS-CoV ( 1, 2). It is caused by a new coronavirus, called SARS-COV-2. COVID-19 was first found in Wuhan, China, in December of 2019.
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